Ca-Dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2

Ca-Dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2 Frank Schumann, Helen Hoffmeister, Reto Bader, Maren Schmidt, Ralph Witzgall & Hans Robert Kalbitzer Institute of Biophysics and Physical Biochemistry, Institute of Anatomy, University of Regensburg, 93040 Regensburg, Germany Running Title: Conformational changes in the C-terminal domain of polycystin-2 + The first two authors have contributed equally to this work. *Address correspondence to: Prof. Hans Robert Kalbitzer, Institute of Biophysics and Physical Biochemistry, University of Regensburg, Universitaetsstr. 31, D-93040 Regensburg, Phone: +49(0)941 943 2594, Fax: +49(0)941 943 2479, E-mail: [email protected]